In the USA, the mother was vaccinated at the 36th week with the Moderna vaccine. Now the baby girl was born with Covid 19 antibodies
The first girl with Covid 19 antibodies was also born in the US after Israel. The woman, located in South Florida, is a front-line health worker and received a dose of Moderna vaccine in January while she was 36 weeks pregnant. exactly 3 weeks before delivery.
Antibodies to Sars-CoV-2 (IgG) protein S were detected in the umbilical cord blood at the time of delivery, immediately after birth. The story of this birth is the protagonist of a scientific study conducted by researchers from Florida Atlantic University – Charles E. Schmidt College of Medicine not yet peer-reviewed and available in pre-print version.
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Being born with Covid 19 antibodies
Dr. Paul Giblert and Dr. Chad Rudnick presented their findings in a shared study awaiting publication on MedRxiv, a prepress server for health sciences.
The article explains that maternal vaccination for influenza and other bacterial diseases has been “well studied in terms of safety and efficacy for protecting the newborn from placental antibodies.”
Doctors write that the woman gave birth to a “vigorous, healthy, full-term baby girl” and that “umbilical cord blood antibodies against SARS-CoV-2 protein S were detected at delivery“.
“We have shown that SARS-CoV-2 IgG antibodies are detectable in a newborn’s umbilical cord blood sample after only a single dose of the Moderna COVID-19 vaccine,” they noted. “Therefore, there is the potential for protection and reduction of the risk of Sars-CoV-2 infection with maternal vaccination.”
Doctors point out, however, that more research is needed to verify the safety and efficacy of coronavirus vaccines during pregnancy. In the introduction to the research, the authors explain: “Maternal vaccination against influenza and with the TDaP vaccine (diphtheria-tetanus-acellular pertussis) have been well studied in terms of safety and efficacy in terms of protection of the newborn through the placental passage of antibodies. Similar neonatal protection would be expected after maternal vaccination against Sars-CoV-2 (the virus responsible for Covid-19). There is a significant and urgent need for research regarding the safety and efficacy of Covid vaccination in pregnancy.
Need for research
Gilbert and Rudnick say there is “a significant and urgent need for research regarding the safety and efficacy of vaccination against SARS-CoV-2 during pregnancy.” Speaking to ABC, Rudnick said: “This is a small case in what will be thousands and thousands of babies born to mothers who have been vaccinated in these months. Further studies need to determine how long this protection will last. They need to determine at what level of protection. or how many antibodies a child must have to be protected “.
But what does this mean in terms of protection?
Doctors have not been able to give a definitive answer. The child does have some protection, but it is not known how long the antibodies will last or if they will be sufficient to provide the child with complete protection against the virus. There is still no data on this. Additionally, there are still no COVID-19 vaccines authorized in the United States for children under the age of 16.
What is known is that the baby being born with some protection is a sign that the world “is turning its back on this virus,” Rudnick said. Gilbert said they also knew the baby was probably “one of the first in the world” to be born with the vaccine antibodies. Parents, however, do not have to let their guard down just yet, even if they have recently been vaccinated.
Golden said that there are still too many unknowns: Will antibodies be effective in protecting the child against COVID-19? How many of the COVID-19 antibodies does a mother pass on to her child? How long will the antibodies last?
He used the pertussis vaccine as an example. Mothers who received the vaccine in their infancy carry these antibodies and can pass them on to their babies, which helps protect them initially. But then, around 2 months of age, babies need to get their own vaccinations so they can start building their immune systems, he said.
Rudnick and Gilbert, the two doctors who work at Boca VIPediatrics, agree that there is still a lot to learn. The two doctors say their discovery will be published in BMC Pediatrics in the coming weeks.
Other studies have shown that pregnant women recovering from a COVID-19 infection can transfer some antibodies to their newborns, but the amount is less than expected.
Rudnick and Gilbert hope their discovery will be treated as a “call to action” and prompt researchers to examine how many antibodies newborns can receive from a recently vaccinated mother and how long the protection will last.
As for the mother and her baby, they are fine. Mom also received her second dose of the vaccine.
Research in Israel
But America doesn’t seem to be the first. The research comes from the Hadassah hospital in Jerusalem. The study looked at the umbilical cord blood of 40 newborns and found that all of them had a strong presence of antibodies. Like their mothers vaccinated with Pfizer-Biontech.
The study by researchers at Hadassah University Medical Center, which was only published in MedRxiv and therefore not peer-reviewed, found that in 20 pregnant women in the third trimester who received two injections of the Pfizer vaccine, both mothers and their infants had adequate levels of immunoglobulin G (IgG) antibodies.
“Neonatal protection from infection depends primarily on maternal antibodies transferred across the placenta,” said Dana Wolf, director of the Hadassah Clinical Virology Unit and one of the study’s lead investigators. “We demonstrated efficient placental transfer of IgG antibodies, the type of antibodies that are activated by infection or after vaccination.”
The study was conducted in February shortly after pregnant women in Israel began receiving coronavirus vaccines. The ongoing study also evaluates the antibodies of women previously vaccinated in their pregnancies.
The study is the latest proof that vaccines can indirectly help protect newborns through their mothers. Earlier this month, a separate Israeli study found that vaccinated mothers who are breastfeeding can also pass antibodies through their breast milk to their nursing babies.
Article sources: MedRxiv, jns.org, hadassah.org